This report examines the fundamental human rights issues faced by minority groups in Mexico, focusing on the COVID-19 pandemic. Mexico, a federation of 31 states and Mexico City, has been severely impacted by the pandemic, causing distress and exacerbating socioeconomic inequalities. The crisis affects access to healthcare, food, water, justice, domestic violence, and employment. The pandemic has also increased the violation of indigenous communities’ rights, with government restrictions and closures of courts preventing the spread of the virus. The key actors in this ongoing struggle include the government, corporations, and criminal organizations. Despite the San Andrés Accords, indigenous communities continue to face expropriation, militarization, and threats from the Mexican government. The report calls for prompt, constructive change to address these issues.